منابع مشابه
The contribution of pharmacokinetics and pharmacodynamics to clinical anaesthesia care.
Defining dose requirement, pharmacokinetics and pharmacodynamics Clinical anaesthetists administer doses of drugs to obtain various degrees of drug effect. Some anaesthetic drug effects, such as muscle relaxation, are relatively easy to quantitate, whereas others such as anaesthetic depth are much more difficult. Anaesthetic dose requirement can be defined as the dose of drug that produces a de...
متن کاملSpinal anaesthesia with hyperbaric bupivacaine. Effects of age on neural blockade and pharmacokinetics.
Effects of ageing were studied on the neural blockade and the pharmacokinetics after subarachnoid administration of 0.5% bupivacaine 3 ml in 8% glucose in two groups of 15 male patients, between 20 and 55 yr and older than 55 yr, respectively. The blockade was performed with the patient in the sitting position. Two minutes after the injection the patient was placed in the supine position. The t...
متن کاملPharmacokinetics of rocuronium after bolus and continuous infusion during halothane anaesthesia.
We have studied the pharmacokinetics of a single bolus of rocuronium (Org 9426), followed by an infusion, in eight patients during anaesthesia with halothane and nitrous oxide in oxygen. Neuromuscular block was monitored using train-of-four (TOF) stimulation and recording the force of contraction of the adductor pollicis muscle. Rocuronium was administered as an initial bolus dose of 0.45 mg kg...
متن کاملThe effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia II: Pharmacokinetics.
The addition of adrenaline to solutions of etidocaine or lignocaine for extradural administration resulted in significantly lower plasma koncentrations in both the arterial blood (14% decrease for etidocaine and 43% decrease for lignocaine) and venous blood (35% and 60% decreases for etidocaine and lignocaine respectively). The nett absorption over the first 4 h after administration, measured f...
متن کاملPharmacokinetics of propofol and haemodynamic changes during induction of anaesthesia in uraemic patients.
The pharmacokinetics of an i.v. bolus of propofol 2 mg kg-1 were studied in 10 uraemic patients undergoing renal transplantation and in seven healthy controls matched for age, weight and duration of anaesthesia. Haemodynamic changes during induction of anaesthesia were recorded in the uraemic and in 10 healthy control patients. Pharmacokinetic variables were similar in uraemic and control patie...
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ژورنال
عنوان ژورنال: Continuing Education in Anaesthesia Critical Care & Pain
سال: 2007
ISSN: 1743-1816
DOI: 10.1093/bjaceaccp/mkl058